NP-Thyroid®

(Commercial Product) Tablets

1/4 grain – 2 grain

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

NP-Thyroid® Description1-3

NP Thyroid® is a medication produced from porcine thyroid glands. It is a desiccated thyroid extract containing a combination of levothyroxine (T4) and liothyronine (T3). Each 60 mg of thyroid extract contains approximately 38 mcg of T4 and 9 mcg of T3, though some variability in T4 and T3 content may occur. The inconsistency in hormone concentrations within thyroid extracts contributed to the development of synthetic T4 formulations.

Indications include:

  • Use as replacement or supplemental therapy in patients with hypothyroidism of any cause, except for transient hypothyroidism occurring during the recovery phase of subacute thyroiditis.

Mechanism of Action1-2

T4 is the major active thyroid hormone. The body converts T4 to T3 for metabolic activity. The T4 and T3 provided in Thyroid NP mimic the actions of thyroid hormones normally produced in the human body.   Thyroid hormones in the body provide growth and development of tissues.  The actions of thyroid hormones are extensive, including influencing both catabolic and anabolic metabolism. Thyroid hormones influence the growth and maturation of tissues and increase energy expenditure. NP Thyroid® can be used in patients if they have impairment in T4-to-T3 conversion.

Common1-3

Adverse effects are typically due to overreplacement and resemble hyperthyroid symptoms:

  • Heart related: Palpitations, tachycardia, arrhythmias
  • Nervous System: Anxiety, nervousness, insomnia
  • Gastrointestinal tract: Diarrhea, increased appetite
  • Miscellaneous: Weight loss, heat intolerance, excessive sweating

Contraindications2

  • Known hypersensitivity to any ingredients in NP Thyroid®
  • Untreated thyrotoxicosis
  • Uncontrolled adrenal insufficiency

Precautions2

  • Use carefully in patients with coronary artery disease or arrhythmia
  • Patients with diabetes should be monitored carefully because of changes in glucose metabolism
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. NP Thyroid® (Thyroid Tablets, USP) Prescribing Information. Acella Pharmaceuticals. Revised October 2019. Accessed June 15 2025 https://www.npthyroid.com/wp-content/uploads/2022/01/NP-Thyroid-flat-PI-10-15-19A-FPO.pdf
  2. Clinical Pharmacology [Internet].: Elsevier; accessed May 2025; NP thryoid monograph. https://www.clinicalkey.com/pharmacology/monograph/609?n=NP%20Thyroid
  3. NP Thyroid® Overview. https://npthyroid.com/for-practitioners. Accessed June 15, 2025

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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